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Peptide Directory

Category · 13 peptides

Immune & Mitochondrial

Peptides studied for immune modulation, mitochondrial function, and cellular energy.

CGRPEstablished
A 37-amino-acid sensory neuropeptide that is one of the body's most potent vasodilators and the validated pharmacological target behind modern anti-migraine therapy.
  • Potent vasodilation
  • Pain and nociceptive modulation
  • Bone repair and osseointegration
10 studies
GlutathioneModerate
The body's master endogenous antioxidant tripeptide — foundational redox biology whose supplemental benefits depend heavily on route and formulation.
  • Master intracellular antioxidant
  • Phase II liver detoxification
  • Liver support in fatty liver disease
8 studiesdosing5 stacks
HumaninPreclinical
The first mitochondrial-derived peptide ever described — a cytoprotective, anti-apoptotic signaling molecule encoded inside mitochondrial DNA.
  • Neuroprotection
  • Anti-apoptotic / cytoprotection
  • Metabolic improvement
12 studiesdosing4 stacks
Leu-EnkephalinPreclinical
An endogenous opioid pentapeptide that binds delta and mu opioid receptors to modulate pain signaling and immune activity.
  • Pain modulation
  • Anti-inflammatory activity
  • Immune modulation
1 studies
Met-EnkephalinEmerging
An endogenous opioid pentapeptide that doubles as the opioid growth factor, acting as a tonic brake on cell proliferation and immune activity.
  • Immune modulation
  • Cell proliferation regulation
  • Anti-inflammatory activity
4 studies1 stacks
MOTS-cPreclinical
A 16-amino-acid mitochondrial-derived peptide that activates AMPK to mimic the metabolic effects of exercise and improve insulin sensitivity.
  • Improved insulin sensitivity
  • Exercise mimicry
  • Metabolic homeostasis and fat oxidation
10 studiesdosing4 stacks
NAD+Emerging
The central cellular energy coenzyme whose age-related decline made it the most commercially successful longevity compound of the last decade — though most of the rigorous evidence sits with its oral precursors.
  • Restores age-associated NAD+ decline
  • Supports mitochondrial energy production
  • Activates sirtuin longevity pathways
8 studiesdosing4 stacks
PNC-27Preclinical
A p53-derived research peptide that selectively ruptures the membranes of cancer cells by targeting surface-expressed HDM-2, while sparing normal cells.
  • Selective cancer cell membranolysis
  • Activity across multiple cancer types
  • Non-apoptotic killing mechanism
1 studies
SS-31 (Elamipretide)Moderate
A first-in-class cardiolipin-targeting tetrapeptide that concentrates in the inner mitochondrial membrane to stabilize cristae, protect the electron transport chain, and reduce reactive oxygen species at the source.
  • Mitochondrial membrane stabilization
  • Reduced ROS at the source
  • Preserved ATP production and cardioprotection
9 studiesdosing3 stacks
ThymalinEmerging
A thymus-derived peptide complex used in Russian medicine to restore age-related immune decline and reduce all-cause mortality in the elderly.
  • Immune restoration in aging
  • Reduced all-cause mortality (elderly cohorts)
  • Cytokine and inflammatory modulation
2 studiesdosing4 stacks
ThymogenEmerging
A synthetic Glu-Trp dipeptide bioregulator that targets thymus-dependent cellular immunity and T-cell function.
  • Immune system modulation
  • Thymic function support
  • Enhanced T-cell immunity
2 studiesdosing6 stacks
Thymosin Alpha-1Established
A thymus-derived immune-modulating peptide, approved abroad as Zadaxin for hepatitis, that reshapes rather than simply boosts immune response.
  • Hepatitis B adjunct therapy
  • Immune modulation, not blunt stimulation
  • T-cell and NK-cell enhancement
2 studiesdosing4 stacks
ThymulinEmerging
A zinc-dependent thymic nonapeptide that drives T-lymphocyte differentiation and helps rebalance the aging, inflammation-prone immune system.
  • Immune modulation
  • T-cell maturation
  • NK cell support
2 studiesdosing
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